Tag: Cancer
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New Drug Doubles One-Year Survival in Pancreatic Cancer Trial
Patients who received an experimental drug developed at Northwestern University alongside standard chemotherapy were twice as likely to be alive after one year of treatment, compared to those receiving chemotherapy alone.
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Targeting Novel Long Non-Coding RNA May Improve Glioblastoma Treatment
Scientists have discovered that increased expression of a novel long non-coding RNA drives glioblastoma cell growth alongside a genetic amplification found in more than half of glioblastoma tumors, according to a Northwestern Medicine study published in Nature Cell Biology.
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Long Non-Coding RNA May be a Promising Therapeutic Target for Cancer
Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its potential as a therapeutic target, according to a recent study published in Nature Communications.
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Overlooked Cells Linked to Poor Outcomes in Breast Cancer
A little-studied group of cancer cells circulating in the bloodstream may play a bigger role in breast cancer progression than previously thought, according to new research published in Science Translational Medicine that sheds light on how the disease spreads and why some patients fare worse than others.
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Transcription Factors Form Continuous ‘Circuit’ That Regulates T-cell Exhaustion
Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion and migration during viral infection, which may inform future therapeutic strategies for managing infections and cancer, according to a recent Northwestern Medicine study.
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Fructose Uptake in Immune Cells Promotes Glioblastoma Growth
Northwestern Medicine scientists have discovered that specialized immune cells within the glioblastoma tumor microenvironment metabolize fructose to suppress immune responses and promote tumor growth, according to a recent study published in the Proceedings of the National Academy of Sciences.
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Calcium Signaling Channels Regulate Neuroinflammation and Motivation
Northwestern Medicine scientists have discovered how calcium signaling channels in the brain’s immune cells regulate neuroinflammation and promote the development of behaviors associated with affective mood disorders, according to a recent study published in Science Signaling.
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CAR T-cell Therapy Improves Survival in Relapsed or Refractory Lymphoma
CAR T-cell immunotherapy improved progression-free and overall survival in patients with relapsed or refractory marginal zone lymphoma, according to a recent clinical trial published in The Lancet.
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Trashing Cancer’s ‘Undruggable’ Proteins
Northwestern scientists have developed polymers capable of grabbing proteins and directing them to the cell’s waste-disposal machinery, potentially triggering cancer cell death.
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Targeting STING Pathway Triggers Cytotoxic and Immune Responses Against Meningioma
Northwestern Medicine scientists have discovered a potent immunotherapy approach for treating meningiomas, the most common type of primary brain tumor, according to a recent study published in Nature Communications.
