Tag: Cancer
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Calcium Signaling Channels Regulate Neuroinflammation and Motivation
Northwestern Medicine scientists have discovered how calcium signaling channels in the brain’s immune cells regulate neuroinflammation and promote the development of behaviors associated with affective mood disorders, according to a recent study published in Science Signaling.
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CAR T-cell Therapy Improves Survival in Relapsed or Refractory Lymphoma
CAR T-cell immunotherapy improved progression-free and overall survival in patients with relapsed or refractory marginal zone lymphoma, according to a recent clinical trial published in The Lancet.
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Trashing Cancer’s ‘Undruggable’ Proteins
Northwestern scientists have developed polymers capable of grabbing proteins and directing them to the cell’s waste-disposal machinery, potentially triggering cancer cell death.
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Targeting STING Pathway Triggers Cytotoxic and Immune Responses Against Meningioma
Northwestern Medicine scientists have discovered a potent immunotherapy approach for treating meningiomas, the most common type of primary brain tumor, according to a recent study published in Nature Communications.
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HPV Cancer Vaccine Slows Tumor Growth, Extends Survival in Preclinical Model
Northwestern scientists have discovered that systematically changing the orientation and placement of a single cancer-targeting peptide can lead to drug formulations that supercharge the immune system’s ability to attack tumors.
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Targeting Cellular Mechanisms May Improve Immune Response in Chronic Infections
Northwestern Medicine scientists have identified cellular mechanisms that cause immune cells to differentiate and ultimately lose function during viral infection, findings that could improve therapeutic strategies for controlling chronic infection, according to a recent study.
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Combination Treatment May Slow Disease Progression in Advanced Sarcoma
An oral combination treatment may prevent disease progression in patients with advanced leiomyosarcoma, one of the most common subtypes of soft tissue sarcoma, according to a recent study published in The Lancet Oncology.
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AI Model May Improve RNA Sequencing Research
Scientists in the laboratory of Rendong Yang, PhD, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications.
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Non-invasive Approach Predicts Chemotherapy Response in Glioblastoma
Northwestern Medicine scientists have developed a new non-invasive approach that could help better determine which patients with glioblastoma are responding favorably to chemotherapy treatment and inform future treatment plans, according to a recent study published in Nature Communications.
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New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies
Northwestern Medicine scientists have discovered new mechanisms underlying transcriptional initiation and elongation control that support proper gene expression, which may inform targeted therapeutic approaches for many diseases, according to a recent study published in Molecular Cell.
