Tag: Biochemistry and Molecular Genetics
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New Function Discovered for Protein Important in Leukemia
A new study has identified a previously unobserved function of a protein found in the cell nuclei of all flora and fauna, playing a role promoting gene transcription.
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Study Identifies Potential Therapeutic Target for Colon Cancer
Northwestern Medicine scientists have discovered that inhibiting the GATA6 protein in mouse models of colon cancer reduced tumor growth and improved survival, underscoring the potential of a new therapeutic target for colon cancer, according to a recent study published in Science Advances.
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Reprogramming Compromised Immune Cells to Fight Cancer
Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to work against tumors, according to a study published in Science Advances.
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Genomic ‘Memory’ Governs the Building Blocks of Life, Study Reveals
Northwestern Medicine scientists have discovered new details about how the human genome produces instructions for creating the building blocks of life, according to a new study published in Science Advances.
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Uncovering the Molecular Drivers of B-cell Lymphoma Tumor Growth
Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a study published in the Journal of Clinical Investigation.
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Novel Mechanism Eliminates ‘Bad’ Enzyme During Gene Expression
Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates ‘bad’ transcriptional elongation enzymes during gene expression, findings that may inform the understanding of adrenal diseases, according to a recent study published in Science Advances.
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Transcription Factor Binding Sites May Help Explain Underlying Causes of Many Diseases
Investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, findings that may improve the understanding of underlying causes of developmental disorders and cancer, according to a recent study.
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Mitochondria May Be a Promising Therapeutic Target for Inflammatory Diseases
Northwestern scientists have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling pathways, according to a recent study published in Science Advances.
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Novel Technique May Accelerate Study of Gene Regulation
Investigators from the laboratory of Ali Shilatifard, PhD, have developed a novel technique to precisely and efficiently study gene regulation, which may accelerate the development of new therapeutic strategies, according to a recent study published in Molecular Cell.
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Study Shows Diabetes Drug Lowers Blood Sugar by Interfering With Mitochondria
A new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels.
