Tag: Biochemistry and Molecular Genetics
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Novel Mechanism Eliminates ‘Bad’ Enzyme During Gene Expression
Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates ‘bad’ transcriptional elongation enzymes during gene expression, findings that may inform the understanding of adrenal diseases, according to a recent study published in Science Advances.
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Transcription Factor Binding Sites May Help Explain Underlying Causes of Many Diseases
Investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, findings that may improve the understanding of underlying causes of developmental disorders and cancer, according to a recent study.
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Mitochondria May Be a Promising Therapeutic Target for Inflammatory Diseases
Northwestern scientists have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling pathways, according to a recent study published in Science Advances.
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Novel Technique May Accelerate Study of Gene Regulation
Investigators from the laboratory of Ali Shilatifard, PhD, have developed a novel technique to precisely and efficiently study gene regulation, which may accelerate the development of new therapeutic strategies, according to a recent study published in Molecular Cell.
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Study Shows Diabetes Drug Lowers Blood Sugar by Interfering With Mitochondria
A new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels.
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Shaking Sensor Continuously Monitors Inflammation
Northwestern University scientists have designed a new implantable device that can monitor fluctuating levels of proteins within the body in real time.
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Esteemed Molecular Biologist Named Winner of 2025 Kimberly Prize
Distinguished biochemist Ron Evans, PhD, director of the Gene Expression Laboratory and professor at the Salk Institute for Biological Studies, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.
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Understanding How Deadly Lung Cancers Control the Local Immune System
Northwestern Medicine scientists have discovered how a protein in a deadly type of lung cancer can control how the immune system responds to the tumor, according to a study published in the Proceedings of the National Academy of Sciences.
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Intercellular Mechanisms Regulate Gene Expression in Cancer Cells
Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.
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‘Feedback Loop’ Promotes Cancer Cells’ Adaption to Molecular Stress
Investigators from the laboratory of Marc Mendillo, PhD, have discovered new cellular regulators of an established cancer cell transcription factor linked to cancer cell resilience and tumor progression, according to findings published in the Proceedings of the National Academy of Sciences.
