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Experimental Drug Shows Promise for Rare Genetic Disorder
A new experimental therapy has shown encouraging results in treating a rare and progressive lysosomal storage disorder, according to findings from a multi-year clinical trial published in the New England Journal of Medicine.
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New Treatment Directions for Rare Brain Disorder
A Northwestern Medicine study has uncovered a promising new therapeutic approach for a rare genetic brain disorder, according to findings published in Nature Communications.
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Novel Mechanism Regulates Essential Enzyme Production in Kidneys
Scientists have discovered previously unknown cellular mechanisms that regulate the production of renin, an essential enzyme in the kidney, findings that could improve the understanding of how the kidney regulates its function and how chronic kidney disease develops, according to a recent study published in Cell.
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Post-Stroke Injection Protects the Brain in Preclinical Study
Northwestern University scientists have developed an injectable regenerative nanomaterial that helps protect the brain during the vulnerable window after a patient suffers a stroke.
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Investigating HIV’s Hidden Immune Evasion Strategy
A Northwestern Medicine study published in Nature Communications has revealed how HIV can protect infected cells by altering the sugars on their surface, hindering the host immune system and avoiding detection.
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Gestational Diabetes Rose Every Year in the US Since 2016
Gestational diabetes rose every single year in the U.S. from 2016 through 2024, according to a new Northwestern Medicine analysis of more than 12 million U.S. births.
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Understanding the Link Between Nucleotide Metabolism and Chromatin Assembly
A Northwestern Medicine study has revealed a connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, according to findings published in Molecular Cell.
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Tanning Beds Triple Melanoma Risk, Potentially Causing Broad DNA Damage
Tanning bed use is tied to almost a threefold increase in melanoma risk, and for the first time, scientists have shown how these devices cause melanoma-linked DNA damage across nearly the entire skin surface, according to a recent study.
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Hypervigilance, Anxiety Linked to Poor Treatment Outcomes in Esophageal Disorder
Increased esophageal hypervigilance and anxiety were associated with worse post-treatment symptoms and poor quality of life in patients with achalasia, a rare esophageal motility disorder, according to a recent Northwestern Medicine study.
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Targeting Aberrant Learning May Improve Parkinson’s Treatment
Northwestern Medicine scientists have discovered that targeting neuronal signaling controlling aberrant learning in the striatum may improve the efficacy of a first-line therapy for Parkinson’s disease and has the potential to reduce therapy-related side effects, according to a recent study published in Science Advances.
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Shape-Shifting Cell Channel Reveals New Target for Precision Drugs
In a new study published in Nature Communications, Northwestern scientists have uncovered how a critical membrane pathway controls the flow of chemical messages responsible for everything from brain activity to inflammation.
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2025 Year in Review
Feinberg experienced a year of discovery and scientific achievement in 2025, from honors and awards to unprecedented research discoveries.
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Scientists Map the Human Genome in 4D
In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date of the genome’s three‑dimensional organization across time and space, according to a new study published in Nature.
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2025 in Scientific Imagery
From elucidating cellular mechanisms underlying tissue regeneration to developing novel biomaterials to improve organ function, Feinberg investigators have provided stunning new snapshots of biological processes invisible to the naked eye.
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NU-9 Halts Alzheimer’s Disease In Animal Model Before Symptoms Begin
In a new study, scientists have identified a previously unknown driver of Alzheimer’s disease, and an experimental drug developed at Northwestern University has demonstrated further promise as an early intervention to treat the disease.
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Exploring the Connection Between Gene Expression and Aging
Northwestern Medicine scientists have discovered how molecular “traffic controllers” in cells influence aging and cellular senescence — a state where cells stop dividing but remain metabolically active.
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Common Virus ‘Rewires’ Intracellular Mechanisms to Promote Infection
Investigators from the laboratory of Derek Walsh, PhD, have discovered how human cytomegalovirus rewires intracellular mechanisms to control the movement of the cell nucleus and promote infection, according to a recent study.
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Noninvasive Treatment Boosts Immune Response Against Glioblastoma
Northwestern Medicine scientists, along with collaborators from the Washington University School of Medicine, have developed a noninvasive nanomedicine approach that may improve the treatment of glioblastoma, according to a recent study published in the Proceedings of the National Academy of Sciences.
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Beidas Elected Co-Editor-in-Chief of Implementation Science
Rinad Beidas, PhD, the chair and Ralph Seal Paffenbarger professor of Medical Social Sciences, has been elected the next co-editor-in-chief of Implementation Science, the field’s flagship journal, effective January 1, 2026.
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RNA ‘Quality Control’ System Breaks Down in ALS
A Northwestern Medicine study has shed light on a critical molecular mechanism underlying amyotrophic lateral sclerosis (ALS), according to findings published in the journal Neuron.