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Subcutaneous Therapy Improves Inflammatory Bowel Disease Treatment
Subcutaneous delivery of an anti-TNF inhibitor therapy improved remission rates compared to placebo in patients with moderate-to-severe Crohn’s disease and ulcerative colitis who previously completed intravenous anti-TNF therapy, according to clinical trial results published in the journal Gastroenterology.
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The Heart Health Benefits of Urban Green and Blue Spaces
New Northwestern research shows that being near and having more exposure to urban green space and blue (water) space is linked to lower odds of having coronary artery calcification in middle age.
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Understanding the Role of RNA Methylation in Cancer
RNA modifications could serve as a therapeutic target for certain types of cancer, according to a new study published in Molecular Cell which sheds new light on the complex process underlying RNA transcription.
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Scientists Discover a Cause of Lupus and a Possible Way to Reverse It
Scientists have discovered a molecular defect that promotes the pathologic immune response in lupus and demonstrated that reversing the defect may potentially reverse the disease.
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Intracellular Mechanisms Promote Spread of Deadly Bacterial Infection
Northwestern Medicine investigators have discovered novel protein mechanisms that promote the rapid spread of Vibrio vulnificus, a rare but lethal bacteria that can cause vibriosis and sepsis, according to findings published in Proceedings of the National Academy of Sciences.
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Remembering Pioneering Pharmacologist V. Craig Jordan
V. Craig Jordan, PhD, the groundbreaking pharmacologist known as the “father” of breast cancer drug Tamoxifen, has died at 76.
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Blood Test Could Provide Snapshot of Overall Health
Circulating protein levels may serve as a biomarker for cardiorespiratory fitness, an important but previously hard-to-measure component of overall health, according to a study published in Nature Medicine.
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B Vitamins May Help Those with Artery Disease Walk Farther
Vitamin B3 supplements may help people with peripheral artery disease walk farther, according to a Northwestern Medicine-led clinical trial published in Nature Communications.
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Medical Student Investigates Racial and Ethnic Disparities in Medicaid Disenrollment
Kranti Rumalla, a second-year medical student at Feinberg, was the lead author of a study that found racial disparities among patients who were disenrolled from Medicaid coverage after the end of the COVID-19 Public Health Emergency.
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Protein May Hold Key to Transplant Tolerance
Northwestern Medicine investigators have uncovered how a single protein contributes to heart transplant tolerance in mice, according to a study published in the Proceedings of the National Academy of Sciences.
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Combination Therapy May Improve Outcomes for Advanced Bladder Cancer
Patients with immunotherapy-resistant bladder cancer who received a novel combination treatment demonstrated improved response to treatment, according to a recent study published in Nature Medicine.
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New Cellular Mechanisms in Parkinson’s Disease Discovered
A pair of recent studies led by Joseph Mazzulli, PhD, have uncovered previously unknown cellular mechanisms involved in neuronal protein aggregation and misfolding, key characteristics of Parkinson’s disease, which may serve as therapeutic targets.
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Embryo’s Signaling Mechanism May Promote Healthy Aging, Combat Neurodegenerative Diseases
Northwestern investigators have identified a novel transcription factor which regulates a signaling mechanism utilized by a fertilized embryo to protect its mother from cellular and environmental stress, according to a recent study to published in the journal Genes and Development.
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Center for Engineering in Vision and Ophthalmology Marks Launch with Symposium
Northwestern’s Center for Engineering in Vision and Ophthalmology recently celebrated its launch with a symposium focused on the work of next-generation engineers and physicians.
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Improving Measurement of Gene Expression in Single Cells
Northwestern Medicine scientists have developed a new technique to identify individual cells for RNA sequencing, which will empower scientists to gather more accurate and precise scientific data, according to details published in Cell Genomics.
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Understanding Inflammation in the Heart
Inflamed heart muscles can mount immune responses even in the absence of immune cells, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
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Improving Advanced Care Planning for Late-Stage Cancer
Multilevel care interventions improved clinician–documented advanced care planning compared with a clinician-level intervention alone for patients with genitourinary cancer, according to recent findings published in JAMA Oncology.
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Investigating DNA Flexibility for the Creation of New Biomaterials
Northwestern investigators have demonstrated how manipulating DNA chemistry can alter its structure and flexibility and enable the realization of new materials useful in medicine and the life sciences, according to a study published in Science Advances.
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Common Blood Pressure Drug May Increase Risk of Bleeding
People with irregular heartbeats taking a common blood pressure drug may be at greater risk of serious bleeding, according to a study recently published in JAMA.
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Goyal and Kennedy Named 2024 Pew Scholars
Yogesh Goyal, PhD, and Ann Kennedy, PhD, have been named 2024 Pew Scholars by The Pew Charitable Trusts, which recognizes promising early-career investigators whose research will accelerate discovery and translation in the biomedical sciences.
