Category: Scientific Advances
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Understanding Cellular Transcription Responses to Oxygen Deprivation
A multiprotein complex is essential for regulating cellular transcription response to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.
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Developing Tools to Explore DNA Methylation
A Northwestern Medicine study has detailed the development of a machine learning model to predict DNA methylation status in cell-free DNA by its fragmentation patterns, according to findings published in Nature Communications.
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Probing Deeper to Understand Protein Expression in Neurons
Northwestern Medicine investigators have developed a method to measure protein expression in an individual neuron type, according to a study published in Molecular Psychiatry.
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Novel Biological Mechanism Discovered That Could Lead to New Treatments for Neurological Disorders, Cancers
The lab of Yongchao C. Ma, PhD, has discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.
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Tracking the Evolution of COVID-19
Scientists have developed a machine-learning approach to track the evolution of the COVID-19 virus and potentially others, according to a study published in the Proceedings of the National Academy of Sciences.
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Novel Role for Metabolites in Cellular Metabolism Discovered
Investigators led by Issam Ben-Sahra, PhD, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used by cells to make DNA and RNA, according to a recent study published in Science.
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Uncovering the Mysteries of Microproteins
Northwestern Medicine scientists have developed a method to identify and characterize microproteins, a development which opens the door for understanding physiology and disease at a molecular level not possible until now, according to findings published in Nature Communications.
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Understanding How a Motor Protein Helps Cells Move
Scientists have characterized how non-muscle myosin assembles in cells using the latest advances in technology only available at Northwestern and a handful of institutions worldwide, according to a study published in the Journal of Cell Biology.
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Treating Cardiovascular Health with Anti-Obesity Medications and Addressing Health Equity
As GLP-1 receptor agonist medications like semaglutide have been shown to be effective at helping patients lose weight, scientists are now asking, whether they can treat other conditions where obesity is a risk factor. Most recently, initial studies have shown that they can reduce the risk of cardiovascular disease by reducing overall body weight.
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Engineered Heart Cells May Improve Understanding of Atrial Fibrillation
A multidisciplinary team of investigators have engineered a more accurate model for studying the underlying mechanisms of atrial fibrillation and treatment response, according to findings published in Science Advances.
