Category: Disease Discoveries
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Mutations in 11 Genes Linked to Deadly Prostate Cancer
Scientists have linked mutations in 11 genes with aggressive prostate cancer, according to the largest-ever study of its kind recently published in JAMA Oncology.
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Combining Immunotherapy and Radiation in Soft Tissue Sarcoma
Combining immunotherapy with radiation may be a promising treatment option for patients with advanced soft tissue sarcoma, according to the results of a Northwestern Medicine clinical trial published in JAMA Oncology.
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Protein-Like Polymers Illuminate the Path to Macular Degeneration Treatment
A new Northwestern study details the use of protein-like polymers to potentially combat neovascular age-related macular degeneration, a leading cause of blindness.
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Pre-Pregnancy Obesity Predicts Future Heart Health
A new Northwestern Medicine study has found obesity before pregnancy is the root cause of future cardiovascular disease, rather than pregnancy complications.
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Investigating the Role of DNA Damage in Cardiac Hypertrophy
A novel cellular pathway regulates DNA damage and structural changes in cardiomyocytes which contributes to the development of cardiac hypertrophy according to a Northwestern Medicine study published in Circulation.
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Weight Loss Drug May Help Patients with Heart Failure
The antidiabetic and weight loss drug semaglutide, sold under the brand names Ozempic and Wegovy, can also help patients with heart failure and obesity lose weight while also improving symptoms and increasing exercise capacity, according to a clinical trial published in the New England Journal of Medicine.
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Small, Implantable Device Could Sense and Treat Cancer
A multi-institutional team of investigators including Northwestern University scientists has received $45 million to fast-track the development of a first-of-its-kind implant to sense and treat cancer.
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Gene Linked to Glioblastoma Stem Cell Self-Renewal and Immunosuppression
Northwestern Medicine scientists have identified how one gene connects glioblastoma stem cell self-renewal to microglia immunosuppression in glioblastoma, according to a new study published in Nature Immunology.
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Novel Intercellular Signaling Mechanisms Promote Melanoma Growth
Investigators have discovered novel intercellular “crosstalk” between epidermal keratinocytes and melanoma cells that promotes cancer growth and metastasis, which could also serve as biomarkers for early cancer detection, according to a recent Northwestern Medicine study.
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Protein Controls Lymphoma Cell Metabolism, Promotes Cancer Growth
Northwestern Medicine investigators have discovered how the PD-1 protein controls essential metabolic processes in tumor cells to promote cancer growth in T-cell non-Hodgkin lymphomas, according to a study published in Nature Cancer.
