Hossein Ardehali, MD, PhD, has discovered that doxorubicin, an effective and commonly used anticancer drug, is causing an accumulation of iron inside of a cell’s mitochondria, resulting in heart damage.
Browsing: Disease Discoveries
After a heart attack, much of the damage to the heart muscle is caused by inflammatory cells that rush to the scene of the oxygen-starved tissue. But the damage is slashed in half when microparticles are injected into the blood stream within 24 hours of the attack, according to preclinical research.
Northwestern Medicine scientists have developed a new prognostic tool for clinicians treating patients with large B-cell lymphoma. The predictive scale enhances the widely used International Prognostic Index.
Published in the Journal of Neuroscience, a discovery by Marco Martina, MD, PhD, associate professor in Physiology, sheds new light on the selective vulnerability of cell types in preclinical models of ataxia.
Variations in DNA sequence may have a significant impact on how humans respond to dengue virus. A group of scientists from Nicaragua, the University of California-Berkeley and Feinberg will seek to uncover genetic variants that make certain people more susceptible to life-threatening forms of the infection.
Second-year medical student Chaitanya Medicherla explores the effects of immune cells on cancer development as part of his Area of Scholarly Concentration research project.
Jennifer Heller, a fifth-year PhD candidate, uses animal models of colitis to better understand how the adaptive immune system becomes dysregulated.
The finding may be useful in shortening drug treatments for those with the disease.
Serdar Bulun, MD, authored an article in the New England Journal of Medicine that combines recent uterine fibroid research into a useful framework for scientists, clinicians, patients and the pharmaceutical industry.
Scientists are working to determine if a specific receptor inhibitor could be used to augment chemotherapy or prevent relapse in individuals with the disease.