Bioinformatic Computational Tool Analyzes Tissue Samples to Discern Disease
A novel integrative computational technique allowed scientists to classify disease conditions at the molecular level using epigenomic data sets.
Browsing: Michelle Mohney
Uncovering the Impact of Protein Mutations in Parkinson’s
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.
‘Cluster Bomb’ Toxin from Cholera Shuts Down Inflammatory Response While Attacking Cells
Northwestern scientists have determined that a toxin secreted by Vibrio cholerae bacteria, the pathogen responsible for cholera, suppresses the body’s normal immune response.
New Approach Shows Promise in Treating Parkinson’s Symptoms
Northwestern Medicine scientists have rescued movement in a mouse model of Parkinson’s disease by restoring the intrinsic discharge of nerve cells within the subthalamic nucleus.
Exploring the Molecular Mechanisms of Ion Channels and Kidney Disease
Northwestern Medicine scientists have discovered the molecular mechanism by which voltage-dependent gates regulate the flow of ions in a unique sub-class of proteins called polycystic receptor potential channels.
Calcium Channels Play Essential Role in Astrocyte Activity
Northwestern Medicine scientists have identified the critical role that a specific ion channel plays in the activity of brain cells called astrocytes.
Mitochondria Linked to Autoimmunity
Northwestern Medicine scientists have demonstrated that a specific mitochondrial protein complex is essential to the immunosuppressive activity of regulatory T-cells.
Delayed Development of Fast-Spiking Neurons Linked to Fragile X
Northwestern Medicine scientists have discovered a delay in the maturation of fast-spiking neurons in the neonatal cortex of a mouse model of Fragile X syndrome, a neurodevelopmental disorder.
Poxvirus Yields New Insights into Protein Synthesis
Northwestern Medicine scientists studied a poxvirus and demonstrated that ribosomes can selectively control the process of protein synthesis known as translation.
Huntington’s Disease Linked to Dysfunction of Brain Structure
Northwestern Medicine scientists have identified a link between Huntington’s disease and dysfunction of the subthalamic nucleus, a component of the basal ganglia, a group of brain structures critical for movement and impulse control.