Byline: Melissa Rohman
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Combination Therapy May Improve Outcomes for Advanced Bladder Cancer
Patients with immunotherapy-resistant bladder cancer who received a novel combination treatment demonstrated improved response to treatment, according to a recent study published in Nature Medicine.
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New Cellular Mechanisms in Parkinson’s Disease Discovered
A pair of recent studies led by Joseph Mazzulli, PhD, have uncovered previously unknown cellular mechanisms involved in neuronal protein aggregation and misfolding, key characteristics of Parkinson’s disease, which may serve as therapeutic targets.
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Embryo’s Signaling Mechanism May Promote Healthy Aging, Combat Neurodegenerative Diseases
Northwestern investigators have identified a novel transcription factor which regulates a signaling mechanism utilized by a fertilized embryo to protect its mother from cellular and environmental stress, according to a recent study to published in the journal Genes and Development.
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Improving Advanced Care Planning for Late-Stage Cancer
Multilevel care interventions improved clinician–documented advanced care planning compared with a clinician-level intervention alone for patients with genitourinary cancer, according to recent findings published in JAMA Oncology.
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Investigating DNA Flexibility for the Creation of New Biomaterials
Northwestern investigators have demonstrated how manipulating DNA chemistry can alter its structure and flexibility and enable the realization of new materials useful in medicine and the life sciences, according to a study published in Science Advances.
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Goyal and Kennedy Named 2024 Pew Scholars
Yogesh Goyal, PhD, and Ann Kennedy, PhD, have been named 2024 Pew Scholars by The Pew Charitable Trusts, which recognizes promising early-career investigators whose research will accelerate discovery and translation in the biomedical sciences.
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Drug Reprograms Immune Responses to Target Glioblastoma
Investigators have discovered that using a novel drug agonist to target the STING pathway in preclinical models of glioblastoma reprogrammed previously suppressed immune responses, according to recent findings published in the Journal of Clinical Investigation.
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Novel Drug May Improve Oxygen Uptake in Hypertrophic Cardiomyopathy
Patients with obstructive hypertrophic cardiomyopathy who received a new drug demonstrated improved oxygen uptake and exercise tolerance, according to a study published in the New England Journal of Medicine.
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Genetic Mechanisms May Reveal Retinal Vascular Disease Therapeutic Targets
Northwestern Medicine investigators have identified novel genetic mechanisms that regulate blood vessel growth in the retina and may also serve as therapeutic targets for retinal vascular disease, according to findings published in Nature Communications.
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New Biomarker May Predict Treatment Response in Bladder Cancer
Patients with metastatic urothelial cancer and increased expression of the NECTIN4 gene had a dramatically better response to antibody treatment than patients with reduced gene expression, according to recent findings published in the Journal of Clinical Oncology.
