Byline: Melissa Rohman
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T-cell Responses Influence Patient Outcomes in SARS-CoV-2 Pneumonia
Northwestern Medicine investigators have identified distinct T-cell responses associated with patient outcomes in unvaccinated individuals with severe SARS-CoV-2 pneumonia, according to findings published in Nature Immunology.
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Non-Neuron Brain Cells Produce a Third of Amyloid Plaque in Alzheimer’s Disease
An international team of investigators have discovered that oligodendrocytes contribute approximately one-third of plaque formation alongside neurons in mouse models of Alzheimer’s disease, according to a recent study published in Nature Neuroscience.
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Oncoprotein Activity Increases Prostate Cancer Progression
Investigators have discovered that aberrant activation of a specific oncoprotein drives key tumor promoting changes in the prostate tissue microenvironment during cancer progression, according to a Northwestern Medicine study published in Nature Communications.
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Intercellular Mechanisms Regulate Gene Expression in Cancer Cells
Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.
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Advancing Pain Medicine Through Innovative Treatments and Precision Care
Get to know Steven P. Cohen, MD, who recently joined Northwestern University Feinberg School of Medicine as the inaugural Edmond I. Eger Professor of Anesthesiology and vice chair of Research and Pain Medicine.
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Investigators Discover New Therapeutic Target for Pediatric Brain Cancers
Northwestern Medicine investigators have discovered that targeting the TIM3 protein in mouse models of low-grade astrocytoma increased survival compared to current immunotherapies, according to recent findings published in the Journal of Clinical Investigation.
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Intense Exercise Doesn’t Increase Risk of Sudden Death in Genetic Heart Disorder
High-intensity exercise does not increase the risk of sudden cardiac death in individuals with congenital long-QT syndrome, a genetic heart disorder, according to findings from a recent study published in Circulation.
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Study Identifies Racial Differences in Rare Endometrial Cancer
Northwestern Medicine investigators have discovered that uterine serous carcinoma tumors in Black patients express more aggressive and immunosuppressive features than tumors in white patients, according to a recent study published in the Proceedings of the National Academy of Sciences.
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‘Feedback Loop’ Promotes Cancer Cells’ Adaption to Molecular Stress
Investigators from the laboratory of Marc Mendillo, PhD, have discovered new cellular regulators of an established cancer cell transcription factor linked to cancer cell resilience and tumor progression, according to findings published in the Proceedings of the National Academy of Sciences.
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Novel AI Model May Enhance Health Data Interoperability
An AI model developed by Northwestern Medicine investigators improved the transformation of EHR data into standardized health resources more efficiently than current methods, according to a recent study published in journal NEJM AI.
