Author: mrr5831
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Examining the Impact of Aging on Critical Cellular Processes
A new Northwestern Medicine study published in the Proceedings of the National Academy of Sciences has explored the impacts of aging on essential cellular processes, findings that could shape the development of future anti-aging therapeutic strategies.
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Radiotherapy Reprograms Immune Response in Rare Skin Cancer
A new Northwestern Medicine study has discovered how radiotherapy alters the immune environment within cutaneous T-cell lymphoma tumors, revealing new molecular signatures associated with long-term treatment response and tumor recurrence.
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New GLP-1 Drug Promotes Weight Loss in Obesity
A new strategy for delivering GLP-1 drugs to patients with obesity or who were overweight resulted in up to an 11 percent reduction in body weight after 36 weeks, according to a randomized phase II clinical trial published in Nature Medicine.
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Cryoprobe Improves Diagnostic Accuracy and Safety in Lung Biopsies
Transbronchial lung biopsy procedures performed with a 1.1 millimeter cryoprobe demonstrated higher diagnostic accuracy and safety than two-millimeter forceps in patients with lung nodules or masses and lung transplant, according to a recent randomized trial published in JAMA.
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Intracellular Mechanisms Promote Tumor Survival During Hypoxia
Northwestern Medicine scientists have for the first time described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advances.
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Immune Cell Circuit Restores Barrier Function in IBD
Scientists have discovered a new communication circuit between immune cells in the intestines, a potential therapeutic target to improve inflammatory bowel disease outcomes, according to a recent study published in the Proceedings of the National Academy of Sciences.
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Exploring Intracellular Communication to Understand Neurodegeneration
Investigators have uncovered a new communication pathway between mitochondria and RNA granules that may improve the understanding of how the toxic buildup of the TDP-43 protein leads to the development of certain neurodegenerative diseases, according to a recent study published in Nature Communications.
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Hormone Impacts Red Blood Cell Production in Anemia
Northwestern Medicine scientists have discovered that the hormone FGF23 reduces the production of red blood cells and may contribute to the development of anemia of chronic kidney disease, according to a recent study published in Blood.
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Novel Synthetic Biomolecule Degrades Disease-Related Proteins
Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can target and degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study.
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Study Uncovers Potential Gene Therapy for Late-Stage Parkinson’s Side-Effects
Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of neurons in the brain may reverse levodopa-induced dyskinesia in patients with late-stage Parkinson’s disease without reducing the symptomatic benefits of levodopa treatment, according to a recent study published in Neuron.
