Steven DeVries, MD, PhD, the David Shoch, MD, PhD, professor of Ophthalmology, has received an International Research Collaborators Award from Research to Prevent Blindness (RPB). The $75,000 grant supports international collaborations that have the potential to accelerate the development of treatments for blinding disorders, positively affecting large populations worldwide for years to come.
The grant will provide DeVries the opportunity to travel to Kyoto, Japan and learn from scientists at Ritsumeikan University about the process of growing 3D retinal organoids from stem cells, a technique first developed in Japan.
“My goal in this project is to apply the physiological and anatomical approaches that we use to evaluate performance at intact cone synapses in the adult retina to cone synapses in retinal organoids,” DeVries said. “If we can intervene to improve the organization and function of cone synapses in organoids, then we may be able to perform the same manipulations during transplantation.”
Additionally, scientists from Ritsumeikan University will also visit Northwestern to learn about state-of-the-art techniques for characterizing the adult cone synapse in DeVries’s lab.
RPB supports several members of the department, including Nicholas J. Volpe, MD, the Chair and George and Edwina Tarry Professor of Ophthalmology and Amani Fawzi, MD, professor of Ophthalmology, and their work in discovering the unanticipated ophthalmologic manifestations of amyotrophic lateral sclerosis (ALS), among other research projects. Gregory Schwartz, PhD, associate professor of Ophthalmology and Jeremy Lavine, MD, PhD, assistant professor of Ophthalmology, have also received the Career Development Award from RPB. In 2015, and again in 2021, the organization also provided an unrestricted grant to support the department’s research into retinal physiology, diabetic retinopathy, macular degeneration, corneal diseases, uveitis and glaucoma.
“Research to Prevent Blindness, through the development of this grant and deciding to fund Dr. DeVries’ work, recognizes the truly unique power of international collaborations and provides an otherwise unavailable funding opportunity,” Volpe said. “Their combined work will help set the stage for successful cone transplantation to patients with diseased retinas.”
RPB is the world’s leading voluntary organization supporting eye research. To date, the organization has awarded grants totaling more than $3 million to Feinberg.
