The work done by Northwestern University Feinberg School of Medicine faculty members (and even some students) is regularly highlighted in newspapers, online media outlets and more. Below you’ll find links to articles and videos of Feinberg in the news.
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As extreme weather conditions escalate across the world, marathons and long-distance races are succumbing to cancellations due to extreme heat and severe flooding, an occurrence that may intensify in the coming years. According to a study published in Nature Scientific Reports, there is a potential 27% decline in the number of viable cities worldwide to host the Olympic marathon by the late twenty-first century due to climate change and the expected summer weather in their regions. Air pollution can lead to nasal congestion, nose inflammation, and irritation in the windpipe, says Ravi Kalhan, MD, Deputy Division Chief of Pulmonary and Critical Care Medicine at Northwestern University. People may have difficulty breathing, Kalhan says, and the inflammation caused in the body by air pollution could increase the risk of clots. People exercising breathe in more potentially dangerous air. Kalhan says “when you exercise [and engage in] high-level training, you breathe in more air and breathe in deeper. The total amount of exposure to the smoke along the surface area of the lung is thought to be higher, resulting in a higher burden of exposure.”
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Over the last several decades, the rates of new cases of lung cancer have fallen in the United States. There were roughly 65 new cases of lung cancer for every 100,000 people in 1992. By 2019, that number had dropped to about 42. But for all that progress, a disparity is emerging: Women between the ages of 35 and 54 are being diagnosed with lung cancer at higher rates than men in the same age group, according to a report published Thursday by researchers at the American Cancer Society. The disparity is small – one or two more cases among every 100,000 women in that age range than among men – but it is significant enough that researchers want to know more. But about 15 to 20 percent of lung cancer cases in women are among those who have never smoked, he said. It’s tricky to tease out why these women develop the disease. They may be exposed to secondhand smoke. Or women might metabolize carcinogens differently from the way men do, said Jyoti Patel, MD, medical director of thoracic oncology at the Lurie Cancer Center at Northwestern Medicine and professor of hematology and oncology at Northwestern University Feinberg School of Medicine.
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Olympic gold medalist Mary Lou Retton is in the intensive care unit battling a rare form of pneumonia. Pneumonia can vary in terms of its severity and there’s lots of different things that can cause pneumonia. “Viruses can cause pneumonia, bacteria can cause pneumonia, and so it can be very dependent on what’s causing the pneumonia, and just how sick you’re actually getting. Pneumonia is still one of the leading causes of death worldwide, and that has been increased with the COVID pandemic because COVID often can cause or increase someone’s susceptibility to pneumonia” said Catherine Myers, MD, assistant professor of pulmonary and critical care. About 20% of people that are hospitalized will end up in the ICU. Vaccines should be prioritized because the risks of the vaccines are much lower than the side effects. Symptoms to watch for include increasing shortness of breath and fevers; if you’re feeling particularly tired, a cold that’s continuing to get worse. any signs of confusion. The earlier you seek out medical care, often times, the better.
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It turns out, the coffee experience is not the same for everyone. How we respond to coffee, whether we like the taste and even how it influences our risk for heart attack or hypertension are all largely determined by our genes. And it’s one gene in particular – CYP1A2 – that appears to strongly influence our body’s sensitivity to caffeine. CYP1A2, the gene, controls an enzyme, also called, CYP1A2, that is responsible for breaking down caffeine and clearing it from the body. What variant of this you have can change how quickly you metabolize caffeine. “If you have genetic variants that allow you to metabolize caffeine more quickly, you’re more likely to consume more caffeine and possibly just tolerate a higher level,” says Marilyn Cornelis, PhD, an associate professor of preventive medicine at Northwestern University’s Feinberg School of Medicine. Genetics can also influence preference for coffee. In a 2021 study, she found that individuals with genetic variants associated with high caffeine sensitivity were less likely to enjoy the bitter taste of dark coffee.
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Vaginal health can be overwhelming topic. Many people are uncomfortable speaking about the issues that arise with their genitalia – which, unfortunately, only further stigmatizes discussions about vaginal health. Yet the vagina is an important part of the body, and its health can have great impacts on your wellness as a whole. It’s no fun to be itchy down there, and often it can be a sign that something is amiss. Yeast infections, bacterial vaginosis (BV), lichen sclerosus, and even vulvar cancer can lead to itchiness around your vulva or inside your vagina, which means it’s important to speak to a medical professional. Sometimes, however, it’s the products you use that can cause this type of itchiness. “Women are told they should use all these vulvar washes and other products, and it’s really poison to the vulva,” says Lauren Streicher, professor of obstetrics and gynecology at Northwestern University. “It’s not meant for vulvar use, even if the product says it is. All these perfumes and chemicals can cause a lot of problems in terms of itching and burning and irritation.”
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Disease X is a term that was created years ago, and the World Health Organization started including it on its list of priority diseases in 2017 alongside familiar diseases like Zika and Ebola. “It is definitely something to worry about, and it is not a matter of if we’re going to have another pandemic — it’s a matter of when,” Pablo Penaloza-MacMaster, PhD, an assistant professor of microbiology-immunology at Northwestern University Feinberg School of Medicine, tells Yahoo Life of the threat posed by undiscovered pathogens and future pandemics. The work didn’t start the day SARS-CoV-2 was identified; it started years before.” Penaloza points out that while the U.S. spends around $800 billion annually on the military, the National Institutes of Health, which funds research around the world, receives around $45 billion per year. “We need to invest more in improving our arsenal against infectious disease,” he says. One possibility could be doing more surveillance and sequencing more viruses in animal reservoirs — going out to the field and identifying new viruses, getting the sequences and then preemptively making vaccines based on those known sequences,” Penaloza says. “And then when there’s a new pandemic, you could think about potentially deploying the most matched vaccine, the one that matches or corresponds better to the sequence of the future pandemic.”
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Researchers at Northwestern, UChicago and UIUC came together to beat out 58 other applications, in a yearlong search process representing 172 institutions across 36 states. The trio of research universities already have a strong history of collaboration, which worked in their favor, said Stephen Quake, head of science at the Chan Zuckerberg Initiative. Chan described Illinois as an “incredible” contributor to recent scientific innovation, citing recent ALS research at Northwestern studying how cells degenerate. The other winning factor: Shana Kelley, PhD, who was tapped as CZ Biohub Chicago president. Kelley, who joined Northwestern as a chemistry and biomedical engineering professor in 2021, has spent decades working in biotechnology and is credited on more than 50 patents. “She works lightning fast,” Chan said of Kelley. Half of human deaths annually can be attributed at least in part to inflammation, Kelley said. These fatal conditions include stroke and neurodegenerative disease. Kelley hopes her team’s research will yield tools to generate precise 3D images of how cells communicate with each other. “We really don’t know what causes inflammation to shift into overdrive,” Kelley said. “We have to get at that if we want to prevent human disease.”
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A new era of biomedical research is launching in Chicago, thanks to a generous $250 million private investment. The C-Z Biohub Chicago is on a mission to pioneer innovative treatments for various diseases. The state-of-the-art research center will harness the collective expertise of three of Illinois’ leading scientific and technology institutions: the University of Chicago, the University of Illinois at Urbana-Champaign and Northwestern University. Shana O. Kelley, PhD, professor at Northwestern University, is the President of the Chan Zuckerberg Biohub Chicago.
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People are motivated to try a vegetarian diet for different reasons – from ethical and religious, to potential health and environmental benefits. But many people have a hard time sticking with it. In fact studies show many self-reported vegetarians actually do consume some animal products. “A lot of people who want to be vegetarian are perhaps not able to,” says Dr. Nabeel Yaseen, of Northwestern University Feinberg School of Medicine. “We wanted to know if genetics is part of the reason,” he says. Yaseen and his collaborators compared the DNA of about 330,000 people, using data from the UK Biobank initiative. The study included 5,324 vegetarians, who had not eaten any animal flesh or products derived from animal flesh for at least one year. “What we can say is that these genes have something to do with vegetarianism,” Yaseen says. “Perhaps vegetarians have different variants of these genes that make them able to pursue a strict vegetarian diet,” he explains. The study is published in PLOS ONE, a peer-reviewed science journal.
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Medicare gives people 65 and older greater access to doctors and health insurance. But this state-run program didn’t wipe out racial and ethnic disparities in medical care. “Medicare has helped tremendously to level the playing field, but there are still some holes,” says Muriel Jean-Jacques, MD, associate vice chair for diversity, equity, and inclusion in the Department of Medicine at Northwestern University Feinberg School of Medicine. “And that stems beyond insurance coverage or cost.” And while many older people live on fixed budgets, people of color often face greater economic challenges and other barriers due to racism. But if you have financial problems, Jean-Jacques says, there’s no reason to hide that from your doctor. Your care team can help you find ways to cover your costs without interrupting your health care. “This is important because many people go years skimping on their medication and not taking it for several months or taking half-doses,” she says, “when actually they’re eligible for some support programs that would allow them to continue access to their medication and to do so more affordably.” Many older people buy Medicare Part D to pay for their medication. But that’s not your only option, and sometimes it’s not the most affordable one. That’s why Jean-Jacques urges older people to ask their health care team about drug assistance programs.