Category: Disease Discoveries
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Localized Genetic Mutations May Serve as Biomarker for Wide Range of Cancers
Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.
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Study Discovers Novel Biomarker for Vascular Aging and Neurodegeneration
Decreased activity of a specific signaling pathway in the brain vessels of aging mice and humans was linked to a decline in vascular function and subsequent neurodegeneration, according to a recent Northwestern Medicine study published in the Journal of Clinical Investigation.
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Exploring How Poxviruses Dismantle Antiviral Responses
Northwestern Medicine investigators led by Derek Walsh, PhD, have discovered how poxviruses disarm and evade mitochondrial-driven antiviral responses for their replication in host cells, according to findings published in Nature Communications.
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New Therapeutic Strategies for Spinal Muscular Atrophy
Modulating the activity of a kinase in motor neurons may help mitigate mitochondrial defects and other symptoms of spinal muscular atrophy, offering a new therapeutic avenue for the devastating disease, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences (PNAS).
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Investigating Drug Combinations for Heart Failure
A common diabetes medication may help some patients with treatment-resistant hypertension slightly lower their high blood pressure and lessen their risk of heart failure events such as stroke, according to an analysis of a clinical trial published in Circulation.
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Investigating the Pathogenesis of Rare Congenital Nerve Disorder
A new Northwestern Medicine study has uncovered previously unidentified intracellular mechanisms in the peripheral nervous system that cause Charcot–Marie–Tooth Type 2B disease, findings that may inform the development of new targeted therapies.
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Studies Identify Novel Underpinnings of Genetic ALS
A pair of recent studies from the laboratory of Evangelos Kiskinis, PhD, have uncovered novel cellular mechanisms that are involved in two types of genetic ALS, providing support for future development of targeted therapies to treat the disease.
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Feinberg Scientists Make New Discoveries at the Forefront of Food Allergy Research
Though treatments for allergies have historically been slow-going, recent research by Feinberg investigators has provided new hope for the future of allergy management.
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One Sleepless Night Can Rapidly Reverse Depression for Several Days
Northwestern scientists have discovered the cause of the ‘punch-drunk’ feeling associated with sleep deprivation, and have found that it also increased dopamine and synaptic plasticity in the brain.
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Study Identifies Genetic Cause for Some Brain Tumors
Scientists have uncovered a genetic explanation for a subset of common brain tumors, according to a study published in Nature Communications.
