Category: Disease Discoveries
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Investigating the Role of DNA Damage in Cardiac Hypertrophy
A novel cellular pathway regulates DNA damage and structural changes in cardiomyocytes which contributes to the development of cardiac hypertrophy according to a Northwestern Medicine study published in Circulation.
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Weight Loss Drug May Help Patients with Heart Failure
The antidiabetic and weight loss drug semaglutide, sold under the brand names Ozempic and Wegovy, can also help patients with heart failure and obesity lose weight while also improving symptoms and increasing exercise capacity, according to a clinical trial published in the New England Journal of Medicine.
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Small, Implantable Device Could Sense and Treat Cancer
A multi-institutional team of investigators including Northwestern University scientists has received $45 million to fast-track the development of a first-of-its-kind implant to sense and treat cancer.
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Gene Linked to Glioblastoma Stem Cell Self-Renewal and Immunosuppression
Northwestern Medicine scientists have identified how one gene connects glioblastoma stem cell self-renewal to microglia immunosuppression in glioblastoma, according to a new study published in Nature Immunology.
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Novel Intercellular Signaling Mechanisms Promote Melanoma Growth
Investigators have discovered novel intercellular “crosstalk” between epidermal keratinocytes and melanoma cells that promotes cancer growth and metastasis, which could also serve as biomarkers for early cancer detection, according to a recent Northwestern Medicine study.
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Protein Controls Lymphoma Cell Metabolism, Promotes Cancer Growth
Northwestern Medicine investigators have discovered how the PD-1 protein controls essential metabolic processes in tumor cells to promote cancer growth in T-cell non-Hodgkin lymphomas, according to a study published in Nature Cancer.
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Study Identifies Novel Cellular Mechanisms Promoting Growth of Uterine Fibroids
Northwestern Medicine investigators have discovered a novel molecular pathway that promotes tumor growth in uterine fibroids, findings that could inform the development of new targeted therapies, according to a recent study.
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Newly Discovered Trigger of Parkinson’s Upends Common Beliefs
A new study suggests that a dysfunction in neurons’ synapses leads to deficits in dopamine and precedes the neurodegeneration previously thought to cause Parkinson’s disease.
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Engineered Probiotic Can ‘Sense’ Inflammatory Bowel Disease
Northwestern Medicine scientists have developed an engineered probiotic capable of detecting inflammatory bowel disease, according to a study published in the Proceedings of the National Academy of Sciences.
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Gene Linked to HIV Viral Load in People of African Ancestry
Naturally occurring variations near the human gene CHD1L may be linked to lower HIV-1 viral load in people of African ancestry, according to a new international, multicenter study published in Nature.
