Byline: Melissa Rohman
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Neural Mechanisms May Serve as Therapeutic Target for Depression
A recent study published in Molecular Psychiatry has identified previously unknown alterations in neural connectivity that promote psychomotor disturbance — a slowing or reduction in movement — in individuals with major depressive disorder.
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Defining Rheumatoid Arthritis Subtypes May Improve Treatments
By profiling the inflammatory cells types in joint tissue biopsy samples, scientists have characterized six subtypes of rheumatoid arthritis, an approach that could help physicians tailor more effective treatment strategies for patients based on disease type, according to findings published in Nature.
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Novel ‘Feeding’ Mechanism Promotes Glioblastoma Treatment Resistance
Northwestern Medicine investigators have discovered that specialized immune cells within the glioblastoma tumor microenvironment use a unique “feeding” mechanism that promotes tumor growth and treatment resistance, according to findings published in the journal Cell Metabolism.
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Localized Genetic Mutations May Serve as Biomarker for Wide Range of Cancers
Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.
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Study Discovers Novel Biomarker for Vascular Aging and Neurodegeneration
Decreased activity of a specific signaling pathway in the brain vessels of aging mice and humans was linked to a decline in vascular function and subsequent neurodegeneration, according to a recent Northwestern Medicine study published in the Journal of Clinical Investigation.
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Semaglutide Trials Show Improvements in Cardiovascular Health, Quality of Life
Two years after the FDA’s approval of semaglutide for chronic weight management, Northwestern Medicine scientists remain at the forefront of investigating the drug’s potential in helping patients who are overweight or have obesity who also have other preexisting health conditions.
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Exploring How Poxviruses Dismantle Antiviral Responses
Northwestern Medicine investigators led by Derek Walsh, PhD, have discovered how poxviruses disarm and evade mitochondrial-driven antiviral responses for their replication in host cells, according to findings published in Nature Communications.
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Bone Transcription Factor Controls Nervous System Gene Expression
An established transcription factor known for bone formation also supports specialized cells in the central nervous system to promote brain tissue stiffness, findings that could inform new therapeutics for neuronal regeneration, according to a Northwestern Medicine study published in Neuron.
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Drug Extends Survival in Prostate Cancer with Genetic Mutations
Men with hormone-resistant prostate cancer and specific genetic mutations who were treated with the drug olaparib survived longer than men treated with traditional hormone therapy, according to a post hoc analysis published in the Journal of Clinical Oncology.
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Comparing Cardiac Monitoring Methods to Detect Atrial Fibrillation After Stroke
Insertable cardiac monitors detected a higher incidence of atrial fibrillation in patients with prior ischemic stroke over a three-year period than standard medical monitoring methods, according to results published in JAMA Neurology, based on long-term findings from the Northwestern Medicine-led STROKE AF clinical trial.
