Byline: Melissa Rohman
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Exploring How Poxviruses Dismantle Antiviral Responses
Northwestern Medicine investigators led by Derek Walsh, PhD, have discovered how poxviruses disarm and evade mitochondrial-driven antiviral responses for their replication in host cells, according to findings published in Nature Communications.
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Bone Transcription Factor Controls Nervous System Gene Expression
An established transcription factor known for bone formation also supports specialized cells in the central nervous system to promote brain tissue stiffness, findings that could inform new therapeutics for neuronal regeneration, according to a Northwestern Medicine study published in Neuron.
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Drug Extends Survival in Prostate Cancer with Genetic Mutations
Men with hormone-resistant prostate cancer and specific genetic mutations who were treated with the drug olaparib survived longer than men treated with traditional hormone therapy, according to a post hoc analysis published in the Journal of Clinical Oncology.
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Comparing Cardiac Monitoring Methods to Detect Atrial Fibrillation After Stroke
Insertable cardiac monitors detected a higher incidence of atrial fibrillation in patients with prior ischemic stroke over a three-year period than standard medical monitoring methods, according to results published in JAMA Neurology, based on long-term findings from the Northwestern Medicine-led STROKE AF clinical trial.
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Aortic Valve Replacement Procedures Show Similar Long-Term Survival Rates
Patients with severe aortic stenosis who underwent a minimally invasive aortic valve replacement procedure had similar long-term survival rates compared to patients who underwent traditional surgery, according to a recent study published in The New England Journal of Medicine.
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New Human Gene Cluster Sequence Discovered
Investigators from the laboratory of Ali Shilatifard, PhD, have discovered a new repeat gene cluster sequence that is exclusively expressed in humans and non-human primates, according to findings published in Science Advances.
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Investigating the Pathogenesis of Rare Congenital Nerve Disorder
A new Northwestern Medicine study has uncovered previously unidentified intracellular mechanisms in the peripheral nervous system that cause Charcot–Marie–Tooth Type 2B disease, findings that may inform the development of new targeted therapies.
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Studies Identify Novel Underpinnings of Genetic ALS
A pair of recent studies from the laboratory of Evangelos Kiskinis, PhD, have uncovered novel cellular mechanisms that are involved in two types of genetic ALS, providing support for future development of targeted therapies to treat the disease.
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Les Turner ALS Symposium Celebrates Research, Patient Care and Community
Northwestern investigators, clinicians, and people living with ALS convened in the Feinberg Pavilion for the 13th annual Les Turner Symposium on ALS to celebrate and share new scientific breakthroughs that improve the understanding of ALS and advancements in treating the disease.
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Study Finds Antidiabetic Drug Effective for Weight-Loss
Tirzepatide, an antidiabetic drug, was found to be effective in helping individuals who are overweight or have obesity and without diabetes lose weight in combination with other lifestyle changes, according to a recent clinical trial published in Nature Medicine.
