A recent study from the laboratory of Joseph Bass, MD, PhD, has revealed how transcription factors within individual cells influence the identity and function of insulin-producing beta cells in the pancreas, according to findings published in Cell Metabolism.
A multidisciplinary team of investigators has developed a first-of-its-kind interactive 3D spatial approach that reveals new therapeutic targets and provides a comprehensive three-dimensional view of glioblastoma tumors, detailed in a recent study published in Cell.
Investigators led by Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine, have discovered previously unknown protein interactions in the heart’s atrium that are critical for normal heart function, according to findings published in the Proceedings of the National Academy of Sciences.
Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future anti-tumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.
A recent study published in Molecular Psychiatry has identified previously unknown alterations in neural connectivity that promote psychomotor disturbance — a slowing or reduction in movement — in individuals with major depressive disorder.
By profiling the inflammatory cells types in joint tissue biopsy samples, scientists have characterized six subtypes of rheumatoid arthritis, an approach that could help physicians tailor more effective treatment strategies for patients based on disease type, according to findings published in Nature.
Northwestern Medicine investigators have discovered that specialized immune cells within the glioblastoma tumor microenvironment use a unique “feeding” mechanism that promotes tumor growth and treatment resistance, according to findings published in the journal Cell Metabolism.
Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.
Decreased activity of a specific signaling pathway in the brain vessels of aging mice and humans was linked to a decline in vascular function and subsequent neurodegeneration, according to a recent Northwestern Medicine study published in the Journal of Clinical Investigation.
Two years after the FDA’s approval of semaglutide for chronic weight management, Northwestern Medicine scientists remain at the forefront of investigating the drug’s potential in helping patients who are overweight or have obesity who also have other preexisting health conditions.