Byline: Melissa Rohman
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Investigating DNA Flexibility for the Creation of New Biomaterials
Northwestern investigators have demonstrated how manipulating DNA chemistry can alter its structure and flexibility and enable the realization of new materials useful in medicine and the life sciences, according to a study published in Science Advances.
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Goyal and Kennedy Named 2024 Pew Scholars
Yogesh Goyal, PhD, and Ann Kennedy, PhD, have been named 2024 Pew Scholars by The Pew Charitable Trusts, which recognizes promising early-career investigators whose research will accelerate discovery and translation in the biomedical sciences.
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Drug Reprograms Immune Responses to Target Glioblastoma
Investigators have discovered that using a novel drug agonist to target the STING pathway in preclinical models of glioblastoma reprogrammed previously suppressed immune responses, according to recent findings published in the Journal of Clinical Investigation.
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Novel Drug May Improve Oxygen Uptake in Hypertrophic Cardiomyopathy
Patients with obstructive hypertrophic cardiomyopathy who received a new drug demonstrated improved oxygen uptake and exercise tolerance, according to a study published in the New England Journal of Medicine.
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Genetic Mechanisms May Reveal Retinal Vascular Disease Therapeutic Targets
Northwestern Medicine investigators have identified novel genetic mechanisms that regulate blood vessel growth in the retina and may also serve as therapeutic targets for retinal vascular disease, according to findings published in Nature Communications.
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New Biomarker May Predict Treatment Response in Bladder Cancer
Patients with metastatic urothelial cancer and increased expression of the NECTIN4 gene had a dramatically better response to antibody treatment than patients with reduced gene expression, according to recent findings published in the Journal of Clinical Oncology.
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New Mechanisms Underlying Tumor Variety in Brain Cancers Discovered
Investigators have discovered new mechanisms underlying intratumor heterogeneity and treatment resistance in meningiomas, the most common type of primary central nervous system tumor, according to a recent study published in Nature Genetics.
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Novel Genetic Mechanisms May Serve as Therapeutic Target Against Glioma
A recent study from the laboratory of Shi-Yuan Cheng, PhD, has identified novel mechanisms underlying RNA splicing events within glioma tumor cells, mechanisms which may serve as novel therapeutic targets, according to findings published in The Journal of Clinical Investigation.
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Honors Day Recognizes Student and Faculty Excellence
Faculty members and fourth-year medical students were recognized for academic and clinical excellence during Feinberg’s Honors Day, held on May 10 in the Hughes auditorium.
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Genetic Variation Linked to Increased Risk of Pick’s Disease
A unique genetic variation in the MAPT gene was associated with increased risk of Pick’s disease, a rare form of frontotemporal dementia, according to a recent study published in The Lancet Neurology.
