A new study explains how mutations in a sodium channel can lead to a disorder causing insensitivity to pain.
Northwestern Medicine scientists have mapped the complete structure of a voltage-gated sodium channel, proteins in the membrane of cells that play an important role in many diseases.
A Northwestern Medicine study has established a new safety index for a common group of chemotherapy drugs, by using a stem cell model to screen such therapies for cardiotoxicity.
Northwestern Medicine scientists identified the process by which a calcium channel called the CRAC channel opens and closes, and how mutations in the channel structures that control its opening cause disease.
Northwestern Medicine scientists have identified the unique targets of two enzymes that activate ubiquitination, a key modification of proteins that controls a variety of cellular processes.
Former and current colleagues, students and friends gathered to celebrated the career of Paula Stern, PhD, an authority on bone and mineral health research, and a respected leader and educator.
Northwestern Medicine scientists have demonstrated an alternate method of signaling used by proteins called group I metabotropic glutamate receptors, a finding that could be used to develop novel drug treatments for many neurological disorders.
A new study shows potential mechanisms leading to the activation of a mutated gene in autosomal dominant polycystic kidney disease.
Northwestern Medicine scientists co-authored a study that identified a blood cell not normally found in the healthy brain that can invade brain tissue after status epilepticus, a type of seizure, and contributes to inflammation.
Northwestern Medicine scientists have received a $7.5 million grant to study how genetic information from African American patients can predict their responses to medications.